Article

<i>In vivo</i> isogenic modelling unveils <i>TP53</i> -associated relapse trajectories in T-cell acute lymphoblastic leukemia

2026-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Many patients with T-cell acute lymphoblastic leukemia (T-ALL) relapse into a treatment-resistant disease. The mechanisms driving relapse remain largely elusive, in part due to the lack of faithful experimental models. Here, we leveraged patient-derived xenograft (PDX) pairs generated from diagnosis and relapse T-ALLs to functionally address the cellular mechanisms driving TP53- altered relapse...

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Literature Corpus work: 770efc19-abe7-58f9-b6ce-70fca78e61cb
DOI: 10.64898/2026.01.19.700255

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