Article

Progerin Can Induce DNA Damage in the Absence of Global Changes in Replication or Cell Proliferation

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, and individuals with HGPS seldom live beyond their mid-teens. The syndrome is commonly caused by a point mutation in the LMNA gene which codes for lamin A and its splice variant lamin C, components of the nuclear lamina. The mutation causing HGPS leads to production of a trunca...

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Literature Corpus work: 76f66713-3790-501d-aa36-9206d96d8cbe
DOI: 10.1101/2024.07.02.601729

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