Article

Healing of chromosomal breaks is impeded in cells expressing progerin

2026-08-15

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, with a life expectancy of less than two decades. HGPS is commonly caused by a point mutation in the LMNA gene which codes for lamin A, a vital component of the nuclear lamina. The HGPS mutation activates a cryptic splice site and leads to production of a truncated, farnesylated form of lamin A re...

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Literature Corpus work: 1f88db6f-24e8-5124-8b68-8f118d6a074d
DOI: 10.64898/2026.08.13.744695

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