Article
Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin.
FEBS letters - 16 Jul 2010
Bruston Francine, Delbarre Erwan, Ostlund Cecilia, Worman Howard J, Buendia Brigitte, Duband-Goulet Isabelle
Abstract excerpt
Mutations in the lamin A/C (LMNA) gene that cause Hutchinson-Gilford progeria syndrome (HGPS) lead to expression of a protein called progerin with 50 amino acids deleted from the tail of prelamin A. In cells from patients with HGPS, both the amount and distribution of heterochromatin are altered....
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