Article

Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P <sub>2</sub> by a phosphotransferase

2021-05-25

Abstract excerpt

Despite their comparatively low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P 3 and PtdIns(3,4)P 2 are uniquely important, as they promote cell growth, survival, and migration. Pathogenic organisms have developed means to subvert phosphoinositide metabolism to promote successful infection and their survival within host organisms. We demonstrate that PtdIns(3,...

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Literature Corpus work: 76f1892e-c465-512b-9b85-cc82674e1e07
DOI: 10.1101/2021.05.25.445663

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