Article

Lipidation of a bacterial effector is critical for bacterial evasion of host-defense

2020-11-05

Abstract excerpt

The Rab32 antimicrobial pathway has been shown to restrict Salmonella Typhi, in mouse macrophages. The broad-host pathogen Salmonella Typhimurium however has evolved a strategy to evade the Rab32 antimicrobial pathway, via its effector protein GtgE. GtgE is a cysteine protease that specifically mediates the cleavage and inactivation of Rab32. Here we show that GtgE association and targeting to membranes is criti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25896e28-1907-5260-b7cf-74bbf2b4f337
DOI: 10.1101/2020.11.05.369652

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lipidation of a bacterial effector is critical for bacterial evasion of host-defenseDOI 10.1101/2020.11.05.369652Read

TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagySemantic proximity Read

Salmonella Typhimurium exploits the reticulophagy/ERphagy receptor RETREG1 to promote infectionSemantic proximity Read

<i>Salmonella</i> Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growthSemantic proximity Read

A small-scale shRNA screen in primary mouse macrophages identifies a role for the Rab GTPase Rab1b in controlling <i>Salmonella</i> Typhi growthSemantic proximity Read

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.Semantic proximity Read

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearanceSemantic proximity Read

Hijacking and Use of Host Lipids by Intracellular PathogensSemantic proximity Read

<i>Salmonella</i> actively modulates TFEB in murine macrophages in a growth-phase and time-dependent mannerSemantic proximity Read

From vacuole to cytosol – Disruptive invasion triggers cytosolic release of <i>Salmonella</i> Paratyphi A and subsequent cytosolic motility favors evasion of xenophagySemantic proximity Read

Coxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole development.Semantic proximity Read

Human-restricted <i>Salmonella</i> exploit preassembled flagella for intracellular motility and vacuolar escapeSemantic proximity Read

FplA From <i>Fusobacterium nucleatum</i> is a Type Vd autotransporter phospholipase with a proposed role in altered host signaling and evasion of autophagySemantic proximity Read