Article
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.
The EMBO journal - 8 Mar 2006
Pendaries Caroline, Tronchère Hélène, Arbibe Laurence, Mounier Joelle, Gozani Or, Cantley Lewis, Fry Michael J, Gaits-Iacovoni Frédérique, Sansonetti Philippe J, Payrastre Bernard
Abstract excerpt
The virulence factor IpgD, delivered into nonphagocytic cells by the type III secretion system of the pathogen Shigella flexneri, is a phosphoinositide 4-phosphatase generating phosphatidylinositol 5 monophosphate (PtdIns5P). We show that PtdIns5P is rapidly produced and concentrated at the entry foci of the bacteria, where it colocalises with phosphorylated Akt during the first steps of infection. Moreover, S....
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