Article
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.
The EMBO journal - 21 Apr 2010
Kerr Markus C, Wang Jack T H, Castro Natalie A, Hamilton Nicholas A, Town Liam, Brown Darren L, Meunier Frederic A, Brown Nat F, Stow Jennifer L, Teasdale Rohan D
Abstract excerpt
3-phosphorylated phosphoinositides (3-PtdIns) orchestrate endocytic trafficking pathways exploited by intracellular pathogens such as Salmonella to gain entry into the cell. To infect the host, Salmonellae subvert its normal macropinocytic activity, manipulating the process to generate an intracellular replicative niche. Disruption of the PtdIns(5) kinase, PIKfyve, be it by interfering mutant, siRNA-mediated...
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