Estimating the carcinogenesis timelines in early-onset versus late-onset cancers and changes across birth cohorts.

Abstract excerpt

Understanding when key mutations occur in cancer is critical for prevention and detection, especially for early-onset cancers that have risen in recent years. Yet, intermediate mutational steps remain difficult to observe. Here, we extend a tumor kinetic model and combine it with long-term cancer registry data to estimate mutational timelines. Using differential equation systems to represent sequential...

Topics

• Humans
• Age of Onset
• Female
• Neoplasms
• Mutation
• Carcinogenesis
• Middle Aged