Article

Sporadic, late-onset, and multistage diseases

2021-12-16

Abstract excerpt

Somatic mutations can cause cancer and have recently been linked with a range of non-malignant diseases. Multistage models can characterise how mutations lead to cancer, and may also be applicable to these other diseases. Here we found the incidence of over 60% of common diseases in UK Biobank were consistent with a multistage model with an ordered sequence of stages, as approximated by a Weibull distribution, wit...

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Literature Corpus work: f97f7e67-2ee0-53f9-bb9e-72b8563c7f57
DOI: 10.1101/2021.12.15.21267843

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