Article
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy.
Nature communications - 22 Jan 2026
De Man Ruben, McDonough John E, Adams Taylor S, Nikola Fadi, Rangel Reina, Anderson Sabina, Manning Edward P, Cala Garcia Juan, Moss Benjamin, Waich Alan, Poli Fernando, Cardenas Rafael, Coarfa Cristian, Song Qi, Bar-Joseph Ziv, Vanaudenaerde Bart M, Wuyts Wim A, Niklason Laura, Raredon Micha Sam B, Yan Xiting, Rosas Ivan O, Kaminski Naftali
Abstract excerpt
Age is a major risk factor for lung disease. We characterized the changing cellular, transcriptional, and genomic landscape of human lung aging using single-cell RNA sequencing. We find that lung aging is cell-type dyssynchronous, with alveolar epithelial and endothelial cells exhibiting the greatest transcriptional changes. Among alveolar epithelial cells, aging is associated with a decreased relative proportion...
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