Article
Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system
2021-09-05
Abstract excerpt
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a system is composed of a Cas12a effector that acts as a deoxyribonucleic acid (DNA)-cleaving endonuclease and a crispr ribonucleic acid (crRNA) that guides the effector to the target DNA. It is considered a key molecule for inducing target-specific gene editing in various living systems. Here, we improved the efficiency and specificity of...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 768a5233-80ff-5dcc-944d-07b14b18d0b4
- DOI
- 10.1101/2021.09.04.458978