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Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes after Traumatic Brain Injury.

Cell transplantation - 1 Oct 2016

Gao Junling, Grill Raymond J, Dunn Tiffany J, Bedi Supinder, Labastida Javier Allende, Hetz Robert A, Xue Hasen, Thonhoff Jason R, DeWitt Douglas S, Prough Donald S, Cox Charles S, Wu Ping

Abstract excerpt

Neural stem cells (NSCs) promote recovery from brain trauma, but neuronal replacement is unlikely the sole underlying mechanism. We hypothesize that grafted NSCs enhance neural repair at least partially through modulating the host immune response after traumatic brain injury (TBI). C57BL/6 mice were intracerebrally injected with primed human NSCs (hNSCs) or vehicle 24 h after a severe controlled cortical impact...

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PMID: 26980267
DOI: 10.3727/096368916X691150

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