Article

Replication gaps underlie BRCA-deficiency and therapy response

2019-09-25

Abstract excerpt

Cancers that are deficient in BRCA1 or BRCA2 are hypersensitive to genotoxic agents, including platinums and other first-line chemotherapeutics. The established models propose that these cancers are hypersensitive because the chemotherapies block or degrade DNA replication forks and thereby create DNA double strand breaks, both of which require functional BRCA proteins to prevent or resolve by mechanisms termed fo...

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Literature Corpus work: c1b48305-9dd2-5e2a-8cce-d7763035b155
DOI: 10.1101/781955

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