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Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer".

DNA repair - 1 Nov 2021

Cantor Sharon B

Abstract excerpt

The toxic lesion emanating from chemotherapy that targets the DNA was initially debated, but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was in part based on the perception that repairing a fractured chromosome necessitated intricate processing or condemned the cell to death. Genetic evidence for the DSB model was also provided by the extreme sensitivity of cells that were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34419699
DOI: 10.1016/j.dnarep.2021.103209
PMCID: PMC9049047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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