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Tumor-associated monocytes promote mesenchymal transformation through EGFR signaling in glioma

30 Aug 2023

Abstract excerpt

The role of brain immune compartments in glioma evolution remains elusive. We profile immune cells in glioma microenvironment and the matched peripheral blood from 11 patients. Glioblastoma exhibits specific infiltration of blood-originated monocytes expressing epidermal growth factor receptor (EGFR) ligands EREG and AREG, coined as tumor-associated monocytes (TAMo). TAMo infiltration is mutually exclusive with...

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PMID: 37652019
DOI: 10.1016/j.xcrm.2023.101177

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