Back to search

Article

Somatic point mutations are enriched in long non-coding RNAs with possible regulatory function in breast cancer

2021-07-20

Abstract excerpt

De novo somatic point mutations identified in breast cancer are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, while the non-coding RNAs (ncRNAs) form a large portion of the mammalian genome, their biological functions are mostly poorly characterized in cancers. In this study, using a newly developed tool, SomaGene, we reanalyze de novo s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
763a1735-2e67-5341-8f9c-6a2f7fcd39ac
DOI
10.1101/2021.07.19.453012
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Somatic point mutations are enriched in long non-coding RNAs with possible regulatory function in breast cancerDOI 10.1101/2021.07.19.453012
Somatic point mutations are enriched in long non-coding RNAs with possible regulatory function in breast cancerSemantic proximity
Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer.Semantic proximity
A New R Package for Categorizing Coding and Non-Coding GenesSemantic proximity
Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data.Semantic proximity
Non-coding mutations reveal cancer driver cistromes in luminal breast cancerSemantic proximity
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements.Semantic proximity
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer.Semantic proximity
GABC: A comprehensive resource and Genome Atlas for Breast Cancer.Semantic proximity
Mining the coding and non-coding genome for cancer drivers.Semantic proximity
A systematic screen of breast cancer patients’ exomes for retrotransposon insertions reveals disease associated genesSemantic proximity
Mapping Non-Coding Epimutations in Breast Cancer: Advancing Epigenetics Towards Precision Medicine.Semantic proximity
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer.Semantic proximity
Select a neighboring publication to make it the new centre.