Article
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer.
Nature communications - 5 Sept 2017
D Antonio Matteo, Weghorn Donate, D Antonio-Chronowska Agnieszka, Coulet Florence, Olson Katrina M, DeBoever Christopher, Drees Frauke, Arias Angelo, Alakus Hakan, Richardson Andrea L, Schwab Richard B, Farley Emma K, Sunyaev Shamil R, Frazer Kelly A
Abstract excerpt
Efforts to identify driver mutations in cancer have largely focused on genes, whereas non-coding sequences remain relatively unexplored. Here we develop a statistical method based on characteristics known to influence local mutation rate and a series of enrichment filters in order to identify distal regulatory elements harboring putative driver mutations in breast cancer. We identify ten DNase I hypersensitive...
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