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Article

Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer.

Communications biology - 7 Jun 2022

Rezaie Narges, Bayati Masroor, Hamidi Mehrab, Tahaei Maedeh Sadat, Khorasani Sadegh, Lovell Nigel H, Breen James, Rabiee Hamid R, Alinejad-Rokny Hamid

Abstract excerpt

Non-coding RNAs (ncRNAs) form a large portion of the mammalian genome. However, their biological functions are poorly characterized in cancers. In this study, using a newly developed tool, SomaGene, we analyze de novo somatic point mutations from the International Cancer Genome Consortium (ICGC) whole-genome sequencing data of 1,855 breast cancer samples. We identify 1030 candidates of ncRNAs that are...

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Identifiers

PMID: 35672401
DOI: 10.1038/s42003-022-03528-0
PMCID: PMC9174258

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