Article
Sequence modeling and design from molecular to genome scale with Evo.
Science (New York, N.Y.) - 15 Nov 2024
Nguyen Eric, Poli Michael, Durrant Matthew G, Kang Brian, Katrekar Dhruva, Li David B, Bartie Liam J, Thomas Armin W, King Samuel H, Brixi Garyk, Sullivan Jeremy, Ng Madelena Y, Lewis Ashley, Lou Aaron, Ermon Stefano, Baccus Stephen A, Hernandez-Boussard Tina, Ré Christopher, Hsu Patrick D, Hie Brian L
Abstract excerpt
The genome is a sequence that encodes the DNA, RNA, and proteins that orchestrate an organism's function. We present Evo, a long-context genomic foundation model with a frontier architecture trained on millions of prokaryotic and phage genomes, and report scaling laws on DNA to complement observations in language and vision. Evo generalizes across DNA, RNA, and proteins, enabling zero-shot function prediction...
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