Article

mGluR4–Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

2025-07-21

Abstract excerpt

Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy neurons is recognized as a key step in the disease process but remains ill-defined mechanistically. Here, we comprehensively assessed the membrane proteome for binding of α-syn fibrils. Expression...

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Literature Corpus work: 13a9d455-7eb8-5edf-84c3-2ebab3c5a43c
DOI: 10.1101/2025.07.16.665194

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