Article
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
Blood - 1 Mar 2004
Barata Joao T, Boussiotis Vassiliki A, Yunes Jose A, Ferrando Adolfo A, Moreau Lisa A, Veiga J Pedro, Sallan Stephen E, Look A Thomas, Nadler Lee M, Cardoso Angelo A
Abstract excerpt
The specific targeting of critical signaling molecules may provide efficient therapies for T-cell acute lymphoblastic leukemia (T-ALL). However, target identification and drug development are limited by insufficient numbers of primary T-ALL cells and by their high rate of spontaneous apoptosis. We established a human interleukin-7 (IL-7)-dependent T-ALL cell line, TAIL7, that maintains several biologic and...
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