Article
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia
3 Feb 2022
Abstract excerpt
Abstract Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis “ph-like” BCP-ALL. Here we show that expression of activated mutant IL7RA in human CD34+hematopoietic stem...