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Article

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.

Blood - 23 Sept 2021

Silva Ana, Almeida Afonso R M, Cachucho Ana, Neto João L, Demeyer Sofie, de Matos Mafalda, Hogan Thea, Li Yunlei, Meijerink Jules, Cools Jan, Grosso Ana Rita, Seddon Benedict, Barata João T

Abstract excerpt

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mutational activation, during leukemogenesis remains...

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Identifiers

PMID: 33970999
DOI: 10.1182/blood.2019000553
PMCID: PMC8462360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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