Article
Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.
Blood - 23 Sept 2021
Silva Ana, Almeida Afonso R M, Cachucho Ana, Neto João L, Demeyer Sofie, de Matos Mafalda, Hogan Thea, Li Yunlei, Meijerink Jules, Cools Jan, Grosso Ana Rita, Seddon Benedict, Barata João T
Abstract excerpt
Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mutational activation, during leukemogenesis remains...
Topics
- Animals
- Carcinogenesis
- Gene Expression Regulation, Leukemic
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Neoplasm Proteins
- Neoplasms, Experimental
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, Interleukin-7
- Signal Transduction