Article
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL.
Advances in biological regulation - 1 May 2021
Rodrigues Gisele O L, Cramer Sarah D, Winer Hila Y, Hixon Julie A, Li WenQing, Yunes José Andres, Durum Scott K
Abstract excerpt
The IL-7 pathway is required for normal T cell development and survival. In recent years the pathway has been shown to be a major driver of acute lymphoblastic leukemia (ALL), the most common cancer in children. Gain-of-function mutations in the alpha chain of the IL-7 receptor found in ALL patients clearly demonstrated that this pathway was a driver. However mutant IL-7R alone was insufficient to transform...
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