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Article

Neurologic and motor dysfunctions in APP transgenic mice.

Reviews in the neurosciences - 1 Jan 2012

Lalonde Robert, Fukuchi Ken-Ichiro, Strazielle Catherine

Abstract excerpt

The discovery of gene mutations underlying autosomal dominant Alzheimer's disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in...

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Source

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Identifiers

PMID: 23089603
DOI: 10.1515/revneuro-2012-0041
PMCID: PMC3481185

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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