Article

Drug-induced colorectal cancer persister cells show increased mutation rate

2021-05-17

Abstract excerpt

Compelling evidence shows that cancer persister cells limit the efficacy of targeted therapies. However, it is unclear whether persister cells are induced by anticancer drugs, and if their mutation rate quantitatively increases during treatment. Here, combining experimental characterization and mathematical modeling, we show that, in colorectal cancer, persisters are induced by drug treatment and show a 7- to 50-f...

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Literature Corpus work: b6b6a7de-debd-5ac9-af87-7a159f094b02
DOI: 10.1101/2021.05.17.444478

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