Back to search

Article

The oral pathogen <i>Porphyromonas gingivalis</i> resists the antimicrobial peptide LGL13K and evades the D-enantiomer by synonymous mutations in <i>hagA</i>

2023-09-07

Abstract excerpt

Porphyromonas gingivalis is a keystone pathogen for periodontal disease. The bacteria are black-pigmented and require heme for growth. P. gingivalis exhibit resistance to many antimicrobial peptides, including the L-enantiomer of the antimicrobial peptide GL13K, which contributes to their success in the oral cavity. P. gingivalis W50 was resistant to LGL13K but susceptible to the stereo-isomer DGL13K. Upon prolo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
75bce517-a2a4-5714-8340-966fea0554aa
DOI
10.1101/2023.09.07.556717
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The oral pathogen <i>Porphyromonas gingivalis</i> resists the antimicrobial peptide LGL13K and evades the D-enantiomer by synonymous mutations in <i>hagA</i>DOI 10.1101/2023.09.07.556717
The oral pathogen Porphyromonas gingivalis gains tolerance to the antimicrobial peptide DGL13K by synonymous mutations in hagA.Semantic proximity
<i><scp>P</scp>orphyromonas gingivalis</i> and related bacteria: from colonial pigmentation to the type <scp>IX</scp> secretion system and gliding motilitySemantic proximity
Engineering Dual-Target Chimeric Lysins for Synergistic Eradication of <i>Porphyromonas gingivalis</i>Semantic proximity
Resistance of Porphyromonas gingivalis ATCC 33277 to direct killing by antimicrobial peptides is protease independent.Semantic proximity
Resisting the resistance: the antimicrobial peptide DGL13K selects for small colony variants of Staphylococcus aureus that show increased resistance to its stereoisomer LGL13K, but not to DGL13K.Semantic proximity
Innocent until proven guilty: <i>Tannerella forsythia</i> may attenuate the virulence of <i>Porphyromonas gingivalis</i>Semantic proximity
Complete Genome Sequence of the Oral Pathogenic Bacterium <i>Porphyromonas gingivalis</i> Strain W83Semantic proximity
Life Below the Gum Line: Pathogenic Mechanisms of<i>Porphyromonas gingivalis</i>Semantic proximity
Subgingival colonization by <i>Porphyromonas gingivalis</i>Semantic proximity
Participation of the secreted dipeptidyl and tripeptidyl aminopeptidases in asaccharolytic growth of Porphyromonas gingivalis.Semantic proximity
The <i>C. difficile clnRAB</i> operon initiates adaptations to the host environment in response to LL-37Semantic proximity
Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical ApplicationsSemantic proximity
Select a neighboring publication to make it the new centre.