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Article

The oral pathogen Porphyromonas gingivalis gains tolerance to the antimicrobial peptide DGL13K by synonymous mutations in hagA.

PloS one - 1 Jan 2024

Gorr Sven-Ulrik, Chen Ruoqiong, Abrahante Juan E, Joyce Paul B M

Abstract excerpt

Porphyromonas gingivalis is a keystone pathogen for periodontal disease. The bacteria are black-pigmented and require heme for growth. P. gingivalis exhibit resistance to many antimicrobial peptides, which contributes to their success in the oral cavity. P. gingivalis W50 was resistant to the antimicrobial peptide LGL13K but susceptible to the all-D-amino acid stereoisomer, DGL13K. Upon prolonged exposure to...

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PMID: 39446776
DOI: 10.1371/journal.pone.0312200
PMCID: PMC11500903

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