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Clinical relevant polymorphisms affecting clopidogrel pharmacokinetics and pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program

2018-04-06

Abstract excerpt

<h4>Background: </h4> Variations in several clopidogrel-pharmacogenes have been linked to clopidogrel response variability and clinical outcomes. We aimed to determine the frequency distribution of major polymorphisms on CYP2C19, PON1, ABCB1 and P2RY12 pharmacogenes in Puerto Ricans. <h4>Methods:</h4> This was a cross-sectional, population-based study of 200 unrelated “Guthrie” cards specimens from new...

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Literature Corpus work: 756faf0c-52d2-5f2e-8ea0-0e65c759947c
DOI: 10.20944/preprints201804.0077.v1

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