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Article

Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program.

International journal of environmental research and public health - 30 May 2018

Hernandez-Suarez Dagmar F, Tomassini-Fernandini Jonnalie C, Cuevas Angelica, Rosario-Berrios Anyelis N, Nuñez-Medina Héctor J, Padilla-Arroyo Dariana, Rivera Nannette, Liriano Jennifer, Vega-Roman Rocio K, Renta Jessicca Y, Melin Kyle, Duconge Jorge

Abstract excerpt

Background: Variations in several clopidogrel-pharmacogenes have been linked to clopidogrel response variability and clinical outcomes. We aimed to determine the frequency distribution of major polymorphisms on CYP2C19, PON1, ABCB1 and P2RY12 pharmacogenes in Puerto Ricans. Methods: This was a cross-sectional, population-based study of 200 unrelated "Guthrie" cards specimens from newborns registered in the Puerto...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29848980
DOI: 10.3390/ijerph15061115
PMCID: PMC6025039

Genes

CYP2C19
ABCB1
P2RY12
PON1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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