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Article

The diversity and clinical implications of genetic variants influencing clopidogrel bioactivation and response in the Emirati population.

Human genomics - 3 Jan 2024

Khasawneh Lubna Q, Alsafar Habiba, Alblooshi Hiba, Allam Mushal, Patrinos George P, Ali Bassam R

Abstract excerpt

BACKGROUND: Clopidogrel is a widely prescribed prodrug that requires activation via specific pharmacogenes to exert its anti-platelet function. Genetic variations in the genes encoding its transporter, metabolizing enzymes, and target receptor lead to variability in its activation and platelet inhibition and, consequently, its efficacy. This variability increases the risk of secondary cardiovascular events, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38173046
DOI: 10.1186/s40246-023-00568-3
PMCID: PMC10765826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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