Article
Pharmacogenetic landscape of clopidogrel in north Indians suggest distinct interpopulation differences in allele frequencies.
Pharmacogenomics - 1 Apr 2014
Giri Anil K, Khan Nazir M, Basu Analabha, Tandon Nikhil, Scaria Vinod, Bharadwaj Dwaipayan
Abstract excerpt
AIM: Clopidogrel, a widely used antiplatelet drug, exhibits high interindividual variability; more than 80% of which could be explained by genetic polymorphisms. We built an allele frequency map of variants affecting clopidogrel response in north Indians. MATERIALS & METHODS: We mined a cross-sectional population-scale genome-wide dataset of 2128 Indo-Europeans residing in north India for presence of variants...
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