Article

Antigen-dependent activation of marginal zone B cells amplifies hypertension

2025-10-17

Abstract excerpt

<h4>Aims</h4> B cells contribute to the development of hypertension, yet, the specific B cell subsets involved, the mechanism underlying their activation, and the relevance of these responses to human disease remain poorly defined. <h4>Methods and results</h4> We used single-cell RNA sequencing, single-cell B cell receptor (BCR) VDJ sequencing, and high dimensional flow cytometry to characterise B cell responses...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 755afcaa-8d6f-503a-91d3-516d765efd05
DOI: 10.1101/2025.10.17.682980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antigen-dependent activation of marginal zone B cells amplifies hypertensionDOI 10.1101/2025.10.17.682980Read

The Effects of Hypertension on Signaling Dynamics in Rare Renal Cell TypesSemantic proximity Read

Intrarenal B cells integrate <i>in situ</i> innate and adaptive immunity in human renal allograft rejectionSemantic proximity Read

Exploring heterogeneity of tumor immune cells and adrenal cells in aldosterone-producing adenomas using single-cell RNA-seq and investigating differences by sexSemantic proximity Read

Human marginal zone B cell development from early T2 progenitors.Semantic proximity Read

Human marginal zone B cell development from early T2 progenitorsSemantic proximity Read

Epigenetic Regulation of Innate and Adaptive Immune Cells in Salt-Sensitive HypertensionSemantic proximity Read

The Landscape and Prognosis Potential of the T-Cell Repertoire in Membranous Nephropathy.Semantic proximity Read

Targeting the APRIL-BAFF axis in IgA nephropathy: preclinical insights from influenza challenge and single-cell spatial profilingSemantic proximity Read

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and bloodSemantic proximity Read

T-cell and B-cell repertoire diversity are selectively skewed in children with idiopathic nephrotic syndrome revealed by high-throughput sequencingSemantic proximity Read

Antigen Presentation-Independent Reciprocal Immune Modulation by <i>HLA-DRB1</i> Allelic Epitopes that Associate with Autoimmune Disease Risk or ProtectionSemantic proximity Read

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndromeSemantic proximity Read