Article

Intrarenal B cells integrate <i>in situ</i> innate and adaptive immunity in human renal allograft rejection

2020-09-26

Abstract excerpt

In human allograft rejection, intrarenal B cell infiltrates identify those with a poor prognosis. However, how intrarenal B cells contribute to rejection is not known. Single cell RNA-sequencing of intrarenal class-switched B cells revealed a unique innate cell transcriptional state resembling murine peritoneal B1 cells (Bin cells). Comparison to the transcriptome of whole renal allograft rejecting tissue revealed...

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Literature Corpus work: 4abc9293-6b88-5788-9743-5e7184779545
DOI: 10.1101/2020.09.26.314377

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