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Article

Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease.

Cell death & disease - 10 Jun 2024

Morcillo Patricia, Kabra Khushbu, Velasco Kevin, Cordero Hector, Jennings Sarah, Yun Taekyung D, Larrea Delfina, Akman H Orhan, Schon Eric A

Abstract excerpt

Genetic mutations causing primary mitochondrial disease (i.e those compromising oxidative phosphorylation [OxPhos]) resulting in reduced bioenergetic output display great variability in their clinical features, but the reason for this is unknown. We hypothesized that disruption of the communication between endoplasmic reticulum (ER) and mitochondria at mitochondria-associated ER membranes (MAM) might play a role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potential, Mitochondrial

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Source

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Identifiers

PMID: 38858390
DOI: 10.1038/s41419-024-06781-9
PMCID: PMC11164949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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