Article
Mitochondrial dysfunction in amyotrophic lateral sclerosis.
Biochimica et biophysica acta - 1 Jan 2010
Shi Ping, Gal Jozsef, Kwinter David M, Liu Xiaoyan, Zhu Haining
Abstract excerpt
The etiology of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains to be better understood. Based on the studies from ALS patients and transgenic animal models, it is believed that ALS is likely to be a multifactorial and multisystem disease. Many mechanisms have been postulated to be involved in the pathology of ALS, such as oxidative stress, glutamate excitotoxicity, mitochondrial damage,...
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