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Article

BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

28 Jun 2012

Abstract excerpt

The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is critical for both normal mammary gland development and malignant transformation. It has been reported that the IGF-1 stimulates breast cancer cell proliferation and is upregulated in tumors with BRCA1/2 mutations. We report here that IGF-1 is negatively regulated by BRCA1 at the transcriptional level in human breast cancer cells. BRCA1...

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PMID: 22739988
DOI: 10.1038/cddis.2012.78

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