Article

Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

2020-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Invasive lobular carcinoma (ILC) is the most common histological subtype of breast cancer, and nearly all ILC tumors express estrogen receptor alpha (ER). However, clinical and laboratory data suggest ILC are strongly estrogen-driven but not equally sensitive to anti-estrogen therapies. We hypothesized that ILC-specific ER transcriptional co-regulators mediate ER functions in ILC and anti-estrog...

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Literature Corpus work: c48266fd-eb18-595c-85e1-07582e704f3d
DOI: 10.1101/2020.12.16.423142

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