Article

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

2021-06-10

Abstract excerpt

The parathyroid hormone receptor 2 (PTH2R) is a class B1 G protein-coupled receptor (GPCR) involved in regulation of calcium transport, nociception mediation, and wound healing. Naturally occurring mutations in PTH2R were reported to cause hereditary diseases, including syndromic short stature. Here we report the cryo-electron microscopy structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide...

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Literature Corpus work: 74fd1f70-0289-53b8-939f-1ec75468aa00
DOI: 10.1101/2021.06.09.447485

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