Article
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021
Wang Xi, Cheng Xi, Zhao Lihua, Wang Yuzhe, Ye Chenyu, Zou Xinyu, Dai Antao, Cong Zhaotong, Chen Jian, Zhou Qingtong, Xia Tian, Jiang Hualiang, Xu H Eric, Yang Dehua, Wang Ming-Wei
Abstract excerpt
The parathyroid hormone receptor 2 (PTH2R) is a class B1 G protein-coupled receptor (GPCR) involved in the regulation of calcium transport, nociception mediation, and wound healing. Naturally occurring mutations in PTH2R were reported to cause hereditary diseases, including syndromic short stature. Here, we report the cryogenic electron microscopy structure of PTH2R bound to its endogenous ligand,...
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