Article

The TCF3-FBXL18 axis regulates KRAS stability to determine cetuximab response in colorectal cancer

2026-03-06

Abstract excerpt

<title>Abstract</title> <p>Background Resistance to anti-EGFR therapy represents a major clinical challenge in metastatic colorectal cancer. Despite the use of RAS mutation status to guide cetuximab administration, a substantial proportion of RAS wild-type tumors develop primary or acquired resistance, underscoring the need to elucidate alternative mechanisms governing EGFR signaling. While protein ubiquitinatio...

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Literature Corpus work: 74d8c689-2a99-513d-873e-6767710f7b03
DOI: 10.21203/rs.3.rs-8906158/v1

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