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Article

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.

Molecular cancer research : MCR - 1 Jul 2017

Mustachio Lisa Maria, Lu Yun, Tafe Laura J, Memoli Vincent, Rodriguez-Canales Jaime, Mino Barbara, Villalobos Pamela Andrea, Wistuba Ignacio, Katayama Hiroyuki, Hanash Samir M, Roszik Jason, Kawakami Masanori, Cho Kwang-Jin, Hancock John F, Chinyengetere Fadzai, Hu Shanhu, Liu Xi, Freemantle Sarah J, Dmitrovsky Ethan

Abstract excerpt

KRAS is frequently mutated in lung cancers and is associated with aggressive biology and chemotherapy resistance. Therefore, innovative approaches are needed to treat these lung cancers. Prior work implicated the IFN-stimulated gene 15 (ISG15) deubiquitinase (DUB) USP18 as having antineoplastic activity by regulating lung cancer growth and oncoprotein stability. This study demonstrates that USP18 affects the...

Topics

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Adenocarcinoma of Lung
Carcinogenesis
Cyclin E
Cycloheximide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Knockdown Techniques

Protein Biosynthesis

Ubiquitin Thiolesterase

Source

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Identifiers

PMID: 28242811
DOI: 10.1158/1541-7786.MCR-16-0369
PMCID: PMC5635999

Genes

USP18
KRAS
ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.PMID 28242811Read ↗

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer.Semantic proximity Read ↗

USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.Semantic proximity Read ↗

USP18 Is Associated with PD-L1 Antitumor Immunity and Improved Prognosis in Colorectal CancerSemantic proximity Read ↗

USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.Semantic proximity Read ↗

Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axisSemantic proximity Read ↗

USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1Semantic proximity Read ↗

The ISG15-specific protease USP18 regulates stability of PTENSemantic proximity Read ↗

USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy inductionSemantic proximity Read ↗

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivitySemantic proximity Read ↗

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.Semantic proximity Read ↗

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinomaSemantic proximity Read ↗

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