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UBE2S promotes 5-fluorouracil resistance in colorectal cancer by activating non-canonical NF-κB/TYMS/TK1 signaling

2026-08-10

Abstract excerpt

<b>Background and Purpose: </b>Chemoresistance to 5-fluorouracil (5-FU) remains a formidable barrier in colorectal cancer (CRC) treatment, largely driven by the metabolic rewiring of pyrimidine synthesis. We investigated the role of the ubiquitin-conjugating enzyme E2S (UBE2S) as a master regulator of this resistance phenotype. <b>Experimental Approach: </b>A 5-FU-resistant HCT116 cell model (HCT116R) was establis...

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Literature Corpus work
d3f61ece-b12a-580c-80d7-4976b718e219
DOI
10.22541/authorea.15007246/v1
Open publication

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UBE2S promotes 5-fluorouracil resistance in colorectal cancer by activating non-canonical NF-κB/TYMS/TK1 signalingDOI 10.22541/authorea.15007246/v1
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