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Article

Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer.

Molecular cancer therapeutics - 1 Oct 2015

Stintzing Sebastian, Zhang Wu, Heinemann Volker, Neureiter Daniel, Kemmerling Ralf, Kirchner Thomas, Jung Andreas, Folwaczny Matthias, Yang Dongyun, Ning Yan, Sebio Ana, Stremitzer Stefan, Sunakawa Yu, Matsusaka Satoshi, Yamauchi Shinichi, Loupakis Fotios, Cremolini Chiara, Falcone Alfredo, Lenz Heinz-Josef

Abstract excerpt

Transmembrane receptors, such as the EGFR, are regulated by their turnover, which is dependent on the ubiquitin-proteasome system. We tested in two independent study cohorts whether SNPs in genes involved in EGFR turnover predict clinical outcome in cetuximab-treated metastatic colorectal cancer (mCRC) patients. The following SNPs involved in EGFR degradation were analyzed in a screening cohort of 108 patients...

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Identifiers

PMID: 26206335
DOI: 10.1158/1535-7163.MCT-15-0121
PMCID: PMC4596768

Genes

EGFR
BRAF
CBL
EPS15
NAE1
SGIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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