Article

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1–COX-2 axis in a reciprocal regulatory network

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>KRAS and BRAF mutations drive colorectal cancer (CRC) progression by sustaining aberrant signaling and promoting therapeutic resistance. Here, we identify TGF-β1-COX-2 axis as a critical regulatory pathway mediated by Furin in CRC harboring KRAS or BRAF mutation. Genetic silencing or pharmacological inhibition of Furin in KRAS-mutant (KPN) and BRAF-mutant (BPN) tumor-derived cells suppr...

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Literature Corpus work: f0bfd1bc-a374-5f36-ae30-e5bd6ced1016
DOI: 10.21203/rs.3.rs-7633807/v1

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