Article

RAC1b Acts Upstream of TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic Cancer

2023-09-26

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease due to early metastatic spread, late diagnosis and the lack of efficient therapies. A major driver of cancer progression and hurdle to successful treatment is the desmoplastic reaction of the tumor stroma, the formation of which is orchestrated by transforming growth factor (TGF)-β. Recent data from pancreatic cancer mouse models have shown that the TGF-β...

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Literature Corpus work: 74b81548-7f6b-51bb-b838-6d4963a342ba
DOI: 10.20944/preprints202309.1790.v1

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RAC1b Acts Upstream of TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic CancerDOI 10.20944/preprints202309.1790.v1Read

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