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Article

Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.

Oncogene - 4 Feb 2010

Xu X, Ehdaie B, Ohara N, Yoshino T, Deng C-X

Abstract excerpt

Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancrea...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Pancreatic Ductal
Share to Cell Transdifferentiation
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Smad4 Protein

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 19901970
DOI: 10.1038/onc.2009.375

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19901970-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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