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Article

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

Cancer cell - 1 Sept 2007

Siveke Jens T, Einwächter Henrik, Sipos Bence, Lubeseder-Martellato Clara, Klöppel Günter, Schmid Roland M

Abstract excerpt

Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras(G12D) by crossing Elastase-Tgfa mice with p48(+/Cre);Kras(+/LSL-G12D) mice. We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic...

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Source

Identifiers

PMID: 17785207
DOI: 10.1016/j.ccr.2007.08.002

Genes

MUC1
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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