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Article

Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.

The Journal of biological chemistry - 27 Sept 2002

Chen Wen-Bin, Lenschow Wolfgang, Tiede Karen, Fischer Jens W, Kalthoff Holger, Ungefroren Hendrik

Abstract excerpt

Overexpression of the small leucine-rich proteoglycan biglycan (BGN) in fibrosis and desmoplasia results from enhanced activity of transforming growth factor-beta (TGF-beta). In pancreatic adenocarcinoma, the tumor cells themselves may contribute to BGN synthesis in vivo, since 8 of 18 different pancreatic carcinoma cell lines constitutively expressed BGN mRNA, as shown by reverse transcription-PCR analysis. In...

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Source

Identifiers

PMID: 12140283
DOI: 10.1074/jbc.M203709200

Genes

BGN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.PMID 12140283Read ↗

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